According to studies, Hepatitis C virus infection (HCV) is estimated to infect 10.4 million patients. This accounts for 13% of all HCV infections worldwide. In Egypt, 15% of overall population is HCV positive while in India approximately 5.5 million people are living with this infection, making this a significant health concern worldwide. Therefore, the discovery of targeted medicines like Sofosbuvir 400mg & Daclatasvir 60mg represents a revolution in the management of chronic hepatitis C virus infection.
Understanding Sofosbuvir 400mg & Daclatasvir 60mg
This combination medicine serves as an active ingredient for Hepcinat plus Tablet for HCV Infection treatment. Clinical trial says Daclatasvir 60mg is a first class HCV NS5A inhibitor. It is effective for all types of all genotypes or strains of a virus (pan genotypic activity).
Sofosbuvir 400mg is other oral NS5B inhibitor. Its characteristics of once daily dosing, pan genotypic activity as well as high barrier to resistance made it an effective and tolerable for HCV treatment. It has few interactions with drugs.When used in combination with Daclatasvir, Sofosbuvir is well tolerated by the patients who have failed previous treatment or untreated.
How Sofosbuvir 400mg & Daclatasvir 60mg works combine?
This medication fights the virus in two ways by targeting different stages of its life cycle.
- Sofosbuvir blocks the abnormal protein (NS5B enzyme), which the virus uses to copy its genetic material. By inhibiting this protein, it stops the virus from replicating.
- Daclatasvir targets the abnormal protein (NS5A), which is important for both virus multiplication (viral RNA replication) and the assembly of new virus particles.
- By blocking both the abnormal proteins simultaneously, the combination medication prevents the virus from multiplying and spreading further. Therefore, the viral load is controlled in the body and prevented from any liver issues.
Therefore, the combination medicine of Hepcinat Plus 60/400mg dosage for HCV infection has proved to be safe and effective in the treatment, particularly for the advanced type.
Does This Combination Medicine Have Side Effects?
As it is a strong medicine to remove the virus from the body, it can have some side effects. These side effects are generally mild and temporary which do not require special medical attention. The common side effects include fatigue, headache, nausea, insomnia etc. It also has few rare side effects like anemia (low red blood cell), dizziness, gastrointestinal problems etc. If a patient experiences any of the serious side effects they must consult their doctor immediately.
What are safety advice for this combination medicine?
- Take the tablet at the same time every day as prescribed by the doctor.
- Patients need to take this medicine every day for either 12 or 24 weeks.
- You should not drive during this treatment because it can cause side effects such as fatigue, dizziness, and blurred vision.
- Doctor may regularly monitor liver function and the levels of hepatitis C virus in the body.
Conclusion
Today, HCV infection remains major health issue globally. If untreated, it can lead to severe liver problem. However, the introduction of advanced treatment options has transformed the way of treating HCV infection. Therefore, with once-daily oral dosing, a low pill burden, good tolerability, and limited drug–drug interactions, this medicine proves to have more efficacy than any other medicines.
FAQs
1. Which common side effects do patients report during this treatment?
A- Many patients generally tolerate this medicine well. But some may experience frequent headache during these treatments.
2. Does HCV infection pose a serious risk to life?
A- Yes, it can pose a serious risk to life if not treated on time. Over time, it may lead to severe liver damage like cirrhosis or liver cancer.
